Isaac I Komnenos
- Født: Omkr 1007
- Ægteskab (1): Catherine of Bulgaria
- Død: Omkr 1060 i en alder af ca. 53 år
 Notater:
Isaac I Komnenos (or Comnenus) (Isaakios I Komnenos; c. 1007 - 1060/61) was Byzantine Emperor from 1057 to 1059, the first reigning member of the Komnenos dynasty. During his brief reign he attempted to restore the depleted finances of the empire and the former strict organization of the government.
Isaac blev gift med Catherine of Bulgaria, datter af Ivan Vladislav of Bulgaria og Maria.
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